Реакция #63634

Уравнение реакции

N-(2-mercaptopropanoyl)thiazolidine-4-carboxylic acid

→

6-methyl-1H,3H-thiazolo[4,3-c][1,4]thiazine-5,8-dione

Выход 50.8%

Растворители

water

Условия реакции

Обработка

1. 1
   Экстракцияextracted with ethyl acetate
2. 2
   ПромывкаThe organic layer was washed with water and brine
3. 3
   Сушкаdried over magnesium sulfate
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated

Методика

Polyphosphoric acid (36 g) was added to N-(2-mercaptopropanoyl)thiazolidine-4-carboxylic acid (1.5 g, 6.78 mmol) and the mixture stirred at 50° for a period of 4 hours. The reaction mixture was then dissolved in water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over magnesium sulfate, filtered and concentrated to give 0.7 g of 6-methyl-1H,3H-thiazolo[4,3-c][1,4]thiazine-5,8-dione as a pale yellow oil.

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