Реакция #63611

Уравнение реакции

2-chloro-N-(5-fluoro-2-methylphenyl)acetamide

hexahydro-3,3-dimethyl-3H-oxazolo[3,4-a]pyrazine

N,N-diethylethanamine

→

N-(5-fluoro-2-methylphenyl)-tetrahydro-3,3-dimethyl-3H-oxazolo[3,4-a]pyrazine-7(8H)-acetamide

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling overnight to room temperature
2. 2
   Другоеthe reaction mixture was evaporated
3. 3
   workup.DISSOLUTIONThe residue was dissolved in trichloromethane
4. 4
   ПромывкаThe solution was washed with water
5. 5
   Другоеdried
6. 6
   Фильтрацияfiltered
7. 7
   Другоеevaporated

Методика

A mixture of 6.6 parts of 2-chloro-N-(5-fluoro-2-methylphenyl)acetamide, 5 parts of hexahydro-3,3-dimethyl-3H-oxazolo[3,4-a]pyrazine, 6.1 parts of N,N-diethylethanamine and 67.5 parts of N,N-dimethylformamide was stirred and heated for 8 hours at about 70° C. After cooling overnight to room temperature, the reaction mixture was evaporated. The residue was dissolved in trichloromethane. The solution was washed with water, dried, filtered and evaporated, yielding 8.5 parts of N-(5-fluoro-2-methylphenyl)-tetrahydro-3,3-dimethyl-3H-oxazolo[3,4-a]pyrazine-7(8H)-acetamide as an oily residue (intermediate 121).

Источник