Реакция #635155

Уравнение реакции

hydrochloric acid

1,2,3-trimethoxybenzene

methyl trans-3-methoxyacrylate

acetic acid

→

methyl trans-3-(2,3,4-trimethoxyphenyl)acrylate

Выход 25.0%

Растворители

ethyl acetate

water

Условия реакции

Обработка

1. 1
   Другоеa reaction
2. 2
   ДругоеAfter completion of the reaction, 30 ml
3. 3
   ПромывкаThe resultant organic layer was washed with water
4. 4
   Концентрированиеconcentrated
5. 5
   Другоеthe resultant concentrated residue was purified by silica gel column chromatography (developing liquid: n-heptane/ethyl acetate=6/1 to 5/1)

Методика

1.68 g of 1,2,3-trimethoxybenzene, 1.34 g of methyl trans-3-methoxyacrylate and 6 mL of glacial acetic acid were mixed, 313 mg of 35 wt % hydrochloric acid was added into the mixture at an inner temperature of 25° C., the added mixture was stirred for 16 hours at the same temperature to cause a reaction. After completion of the reaction, 30 ml, of water and 50 mL of ethyl acetate were added into the reaction liquid, and extraction treatment was conducted. The resultant organic layer was washed with water, then, concentrated, and the resultant concentrated residue was purified by silica gel column chromatography (developing liquid: n-heptane/ethyl acetate=6/1 to 5/1), to obtain 0.63 g of methyl trans-3-(2,3,4-trimethoxyphenyl)acrylate (white solid). 0.92 g of the raw material 1,2,3-trimethoxybenzene was recovered. The yield of methyl 3-(2,3,4-trimethoxyphenyl)acrylate based on the converted 1,2,3-trimethoxybenzene was 55%.

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