Реакция #63416

Уравнение реакции

6-bromo-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline

benzene

ethanol

maleic acid

→

product

Выход 55.0%

1-(2-Aminophenyl)-6-bromo-1,2,3,4-tetrahydroquinoline maleate

Выход 55.0%

Растворители

ether

Условия реакции

Обработка

1. 1
   ФильтрацияThe mixture was then filtered
2. 2
   Другоеto remove the catalyst
3. 3
   Концентрированиеthe filtrate was concentrated under vacuum
4. 4
   Фильтрацияfiltered
5. 5
   Температураto cool
6. 6
   ДругоеThe supernatant was decanted from an oil, which
7. 7
   Другоеseparated
8. 8
   КонцентрированиеThe supernatant was concentrated

Методика

A Parr hydrogenation bottle was charged with 6-bromo-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline (16.7 g, 0.050 mole), 1% platinum-on-carbon (1 g), benzene (100 ml) and ethanol (100 ml). The mixture was shaken under an initial hydrogen pressure of 58 psi until uptake ceased. The mixture was then filtered to remove the catalyst and the filtrate was concentrated under vacuum. The residue was taken up in hot ether (150 ml), filtered, and the filtrate was treated with a hot solution of maleic acid (6.4 g, 0.055 mole) in ether (500 ml). The solution was boiled down to about 300 ml and allowed to cool. The supernatant was decanted from an oil, which separated. The supernatant was concentrated and the process was repeated several times to give 11.4 g (55%) of product. Recrystallization from ethyl acetate afforded the analytical sample, mp 113°-116° C.

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