Реакция #63345

Уравнение реакции

carbon disulphide

3-(1-piperidinylmethyl)phenoxy propanamine

Triethylamine

→

title compound

[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]isothiocyanate

Растворители

acetone

acetone

acetone

Условия реакции

Обработка

1. 1
   Температураthe mixture was heated
2. 2
   Температураat reflux for 45 minutes
3. 3
   ФильтрацияThe resulting suspension was purified by filtration
4. 4
   Другоеthe filtrate evaporated in vacuo
5. 5
   ДругоеThe residue was purified by column chromatography

Методика

A solution of carbon disulphide (3.3 ml) in acetone (8 ml) was added dropwise to a solution of 3-[3-(1-piperidinylmethyl)phenoxy propanamine (12.4 g) in acetone (30 ml) over a 15 minute period, between -5° and -10° C. The solution was cooled to -14° C. and mercury (II) chloride (13.6 g) in acetone (30 ml) was added, during 45 minutes. Triethylamine (16 ml) was added at 0° C. during 15 minutes, and the mixture was heated at reflux for 45 minutes. The resulting suspension was purified by filtration and the filtrate evaporated in vacuo. The residue was purified by column chromatography using methanol as eluant to give the title compound (6 g) as an amber oil.

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