Реакция #63256

Уравнение реакции

potassium iodide

2-propyl-3,4-dichlorophenol

7-bromoheptanoic acid

potassium carbonate

→

desired title product

7-(2-Propyl-3,4-dichlorophenoxy)heptanoic acid

Растворители

methyl ethyl ketone

Условия реакции

Обработка

1. 1
   Температураat reflux overnight
2. 2
   Другоеevaporated in vacuo
3. 3
   workup.ADDITIONEthyl acetate and water were added to the residue
4. 4
   Другоеthe layers were separated
5. 5
   workup.ADDITIONFresh water was added to the organic layer
6. 6
   Другоеthe layers were separated
7. 7
   ПромывкаThe organic layer was washed with a saturated sodium chloride solution
8. 8
   Фильтрацияfiltered through sodium sulfate
9. 9
   Другоеevaporated to dryness
10. 10
    Другоеto give 4.68 g

Методика

A solution of 3.09 g. of 2-propyl-3,4-dichlorophenol, 3.1 g. of 7-bromoheptanoic acid, 3.1 g. of potassium carbonate, and 2.0 g. of potassium iodide in 50 ml. of methyl ethyl ketone was heated at reflux overnight. The reaction mixture was cooled to room temperature and evaporated in vacuo. Ethyl acetate and water were added to the residue and the layers were separated. Fresh water was added to the organic layer, the pH was adjusted to 2.0 with acid, and the layers were separated. The organic layer was washed with a saturated sodium chloride solution, filtered through sodium sulfate, and evaporated to dryness to give 4.68 g. of the desired title product.

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