Реакция #63250

Уравнение реакции

4-(2-propyl-3- chloro-4-acetylphenoxy)butane nitrile

tetramethylguanidinium azide

ethyl acetate

dimethylformamide

→

desired title product

5-[4-(2-Propyl-3-chloro-4-acetylphenoxy)butyl]-tetrazole

Растворители

water

Условия реакции

Обработка

1. 1
   ТемператураThe reaction was cooled
2. 2
   Другоеthe layers were separated
3. 3
   workup.ADDITIONWater was added to the ethyl acetate layer
4. 4
   Другоеthe layers were separated
5. 5
   СушкаThe ethyl acetate was dried
6. 6
   Другоеevaporated to dryness
7. 7
   ДругоеThe residue was purified by chromatography

Методика

A solution of 0.5 g. of 4-(2-propyl-3- chloro-4-acetylphenoxy)butane nitrile and 1.3 g. of tetramethylguanidinium azide in 3 ml. of dimethylformamide was heated overnight at 125° C. The reaction was cooled, ethyl acetate and water were added, and the layers were separated. Water was added to the ethyl acetate layer, the water layer was acidified, and the layers were separated. The ethyl acetate was dried and evaporated to dryness. The residue was purified by chromatography to give the desired title product. NMR.

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