Реакция #63248

Уравнение реакции

5-(2-propyl-3,4dichlorophenoxy)pentyl bromide

sodium cyanide

→

5-(2-propyl-3,4-dichlorophenoxy)pentane nitrile

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   ДругоеThe solution was evaporated in vacuo and ethyl acetate and water
2. 2
   workup.ADDITIONwere added to the residue
3. 3
   ДругоеThe layers were separated
4. 4
   Промывкаthe organic layer was washed several times with a saturated sodium chloride solution
5. 5
   ФильтрацияThe organic solution was filtered through sodium sulfate
6. 6
   Другоеevaporated to dryness
7. 7
   Другоеto give 1.38 g

Методика

A solution of 1.6 g. of 5-(2-propyl-3,4dichlorophenoxy)pentyl bromide and 0.22 g. of sodium cyanide were heated overnight at 75°-85° C. in 50 ml. of dimethylformamide. The solution was evaporated in vacuo and ethyl acetate and water were added to the residue. The layers were separated and the organic layer was washed several times with a saturated sodium chloride solution. The organic solution was filtered through sodium sulfate and evaporated to dryness to give 1.38 g. of the desired sub-title intermediate. NMR.

Источник