Реакция #631387

Уравнение реакции

cyanoacetic acid

1-(2,6-dimethylphenyl)semicarbazide

acetic anhydride

→

N-(2-cyanoacetyl)-1-(2,6-dimethylphenyl)semicarbazide

Растворители

ether

Условия реакции

Обработка

1. 1
   Температураis heated to 80° for 2 hours
2. 2
   ФильтрацияThe reaction mixture is filtered
3. 3
   Промывкаwashed with ether (3X)
4. 4
   Другоеdried

Методика

A mixture of 1 mole of cyanoacetic acid, 1 mole of 1-(2,6-dimethylphenyl)semicarbazide and 300 ml of acetic anhydride is heated to 80° for 2 hours. The mixture is cooled to RT, 50 ml of ether is added and it is stirred at RT overnight. The reaction mixture is filtered, washed with ether (3X) and dried to give N-(2-cyanoacetyl)-1-(2,6-dimethylphenyl)semicarbazide.

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