Реакция #63131

Уравнение реакции

hydrochloric acid

3-tetradecylphenol

acetate

aluminum chloride

→

desired compound

1-(2-Hydroxy-4-tetradecylphenyl)ethanone

Растворители

ether

Условия реакции

Обработка

1. 1
   Температураto cool
2. 2
   Экстракцияextracted several times with ether
3. 3
   Промывкаwashed with water, brine
4. 4
   Другоеdried
5. 5
   ДругоеThe crude material was chromatographed on silica gel
6. 6
   Промывкаeluting with hexane:ethyl acetate (50:1)

Методика

A 20 g portion of 3-tetradecylphenol, acetate was heated at 110° C. and 8.4 g of aluminum chloride was added in portions over a 3 hour period. The mixture was allowed to cool, then diluted with ether, poured onto ice containing 10 ml of concentrated hydrochloric acid and extracted several times with ether. The ether extracts were combined, washed with water, brine and dried. The crude material was chromatographed on silica gel, eluting with hexane:ethyl acetate (50:1), giving 15.8 g of the desired compound, mp 45°-46° C.

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