Реакция #63115

Уравнение реакции

4-tetradecylphenol

acetate

aluminum trichloride

→

desired compound

1-(2-Hydroxy-5-tetradecylphenyl)ethanone

Растворители

chloroform

Условия реакции

Обработка

1. 1
   Температураthe mixture was heated at this temperature for 45 minutes
2. 2
   ТемператураThe mixture was then cooled
3. 3
   Промывкаwashed with 50% aqueous hydrochloric acid
4. 4
   Сушкаwater and dried
5. 5
   ДругоеThe solvents were removed
6. 6
   Другоеthe residue recrystallized from ether-methanol

Методика

A 900 mg portion of 4-tetradecylphenol, acetate was heated at 70° C. under argon and 720 mg of aluminum trichloride was added portionwise. After 2 hours the temperature was raised to 120° C. and the mixture was heated at this temperature for 45 minutes. The mixture was then cooled, diluted with chloroform, washed with 50% aqueous hydrochloric acid then water and dried. The solvents were removed and the residue recrystallized from ether-methanol, giving 850 mg of the desired compound, mp 38.5°-39.5° C.

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