Реакция #630038

Уравнение реакции

1,2,3,4-tetrahydro-1-naphthol

thionyl chloride

→

1,2,3,4-tetrahydro-1-chloronaphthalene

Растворители

pyridine

chloroform

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was cooled with an external ice bath
2. 2
   Температураwith cooling
3. 3
   Концентрированиеconcentrated in vacuo
4. 4
   ПромывкаThe methylene chloride solution was washed with water
5. 5
   Сушкаa 5% sodium bicarbonate solution, water again, dried over sodium sulfate
6. 6
   Другоеevaporated to dryness

Методика

One hundred grams of 1,2,3,4-tetrahydro-1-naphthol were dissolved in 1 liter of chloroform and 53.9 ml of pyridine. The mixture was cooled with an external ice bath and 98.6 ml of thionyl chloride were added over a 1 hour period. The reaction mixture was stirred an additional 2 hours with cooling, concentrated in vacuo, and the residue taken up in 1 liter of methylene chloride. The methylene chloride solution was washed with water, a 5% sodium bicarbonate solution, water again, dried over sodium sulfate, and evaporated to dryness to provide the desired intermediate 1,2,3,4-tetrahydro-1-chloronaphthalene.

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