Реакция #62981

Уравнение реакции

Bromoacetic acid

amine

2-amino-4-benzyloxyphenol

→

bromoamide

2-α-bromoacetamido-4-benzyloxyphenol

Растворители

THF

Условия реакции

Обработка

1. 1
   ФильтрацияAfter 1 hour the reaction mixture was filtered
2. 2
   Другоеthe liquid evaporated to dryness under vacuum
3. 3
   ДругоеThe residue was crystallized from acetic acid (50 ml)

Методика

Bromoacetic acid (13.9 g, 0.01 mole) and dicyclohexyldicarbodiimide (DCCD, 20.6 g, 0.01 mole) were added at room temperature under stirring to the amine ((b), 21.5 g, 0.01 mole) in THF (200 ml). After 1 hour the reaction mixture was filtered and the liquid evaporated to dryness under vacuum. The residue was crystallized from acetic acid (50 ml) to give the bromoamide ((c), 17 g, 50%) as white prisms. The product structure was confirmed by NMR analysis.

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