Реакция #62974

Уравнение реакции

α-chloroacetylchloride

2-aminohydroquinone

diethanolamine

hydrochloride

→

2-(α-chloroacetamido)-hydroquinone

Растворители

acetone

water

Условия реакции

Обработка

1. 1
   Экстракцияextracted with ethylacetate (500 ml)
2. 2
   ДругоеThe solvent was evaporated to dryness
3. 3
   Другоеthe solid residue (4.20 g, 80%) was used without any further purification

Методика

α-chloroacetylchloride (10.1 g, 0.128 mole) was added dropwise under stirring at room temperature to the 2-aminohydroquinone (4.16 g, 0.128 mole) in dry acetone (400 ml) and diethanolamine (2.04 ml, 0.128 mole). The reaction mixture was poured into water and hydrochloride acid (2,000 ml, pH 1), then extracted with ethylacetate (500 ml). The solvent was evaporated to dryness and the solid residue (4.20 g, 80%) was used without any further purification. The structure of the 2-(α-chloroacetamido)-hydroquinone was confirmed by NMR analysis.

Источник