Реакция #62946

Уравнение реакции

5-acetamido-2-mercapto-1,3-thiazole

bromoacetic acid

→

title compound

Выход 67.0%

5-Acetamido-2-carboxymethylthio-1,3-thiazole

Выход 67.0%

Растворители

DMF

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was then removed in vacuo
2. 2
   Промывкаthe solid residue was washed with diethyl ether
3. 3
   ДругоеAfter recrystallization from isopropanol/diethyl ether

Методика

3.48 g (20 mmol) of 5-acetamido-2-mercapto-1,3-thiazole were dissolved in 90 ml of dry DMF, 2.78 g (20 mmol) of bromoacetic acid were added, and the mixture was stirred at room temperature for 2 hours. The solvent was then removed in vacuo, and the solid residue was washed with diethyl ether. After recrystallization from isopropanol/diethyl ether, 3.1 g (67%) of the title compound were obtained.

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