Реакция #62874

Уравнение реакции

4-chloro-5-ethoxycarbonylmethyl-2-(2-methylprop-2-yl)pyrimidine

2-iodo-propane

lithium bis(trimethylsilyl)amide

→

ethyl (RS)-2-[2-(2-methylprop-2-yl)-4-chloropyrimidin-5-yl]-3-methylbutyrate

Условия реакции

Методика

4-chloro-5-ethoxycarbonylmethyl-2-(2-methylprop-2-yl)pyrimidine was reacted with 2-iodo-propane in the presence of lithium bis(trimethylsilyl)amide according to the procedure illustrated in example 6, to give ethyl (RS)-2-[2-(2-methylprop-2-yl)-4-chloropyrimidin-5-yl]-3-methylbutyrate.

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