Реакция #62861

ord-5b626c226c2642a5a780bd9dbe3f6026

Уравнение реакции

O=C([O-])[O-].[Na+].[Na+]
sodium carbonate
Cc1c(Cl)c(C(=O)O)cc([N+](=O)[O-])c1Cl
2,4-dichloro-3-methyl-5-nitrobenzoic acid
O=S([O-])S(=O)[O-].[Na+].[Na+]
Na2S2O4
Cl
HCl
→
Nc1ccc(C(=O)O)cc1
aminobenzoic acid

Реактанты

O=C([O-])[O-].[Na+].[Na+]
sodium carbonate
Cc1c(Cl)c(C(=O)O)cc([N+](=O)[O-])c1Cl
2,4-dichloro-3-methyl-5-nitrobenzoic acid
O=S([O-])S(=O)[O-].[Na+].[Na+]
Na2S2O4
Cl
HCl

Реагенты

Нет

Растворители

O
water
COCCO
glycol monomethyl ether
O
water

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

55 g of 2,4-dichloro-3-methyl-5-nitrobenzoic acid and 141.6 g of Na2S2O4 are boiled in a mixture of 440 ml of glycol monomethyl ether and 440 ml of water for 3 hours. 620 ml of 1/2-concentrated HCl are added to the still warm solution and the mixture is then boiled up once more. After cooling to room temperature, the mixture is poured into 1.5 l of water and brought to pH 5 with sodium carbonate. 24.6 g of aminobenzoic acid are obtained. Melting point: 202°-3°.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US04762844uspto-grants-1988_08