Реакция #62839

Уравнение реакции

potassium hydroxide

3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenoic acid

glycine ethyl ester hydrochloride

triethylamine

→

title compound

Выход 85.0%

N-(3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenoyl)-glycine

Выход 85.0%

Растворители

ethanol

water

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was heated
2. 2
   Температураunder reflux for 30 minutes
3. 3
   workup.ADDITIONwas added
4. 4
   Экстракцияthe obtained aqueous solution was extracted with ethyl acetate
5. 5
   ПромывкаThe ethyl acetate layer was washed with water
6. 6
   Сушкаdried over magnesium sulfate
7. 7
   workup.DISTILLATIONThe solvent was distilled off

Методика

The reaction of 6.1 g of 3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenoic acid with glycine ethyl ester hydrochloride was conducted in the same manner as described in Example 1 except that 6.5 ml of triethylamine was used. Then, a solution of 2.7 g of potassium hydroxide in ethanol was added. The mixture was heated under reflux for 30 minutes. After the completion of the reaction, water was added and the obtained aqueous solution was extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried over magnesium sulfate. The solvent was distilled off to afford 6.1 g (yield 85%) of the title compound as a pale brown oil.

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