Реакция #62830

Уравнение реакции

5-fluoroisatin

triethylamine

methyl isocyanate

→

5-fluoro-1-methylcarbamoylisatin

Выход 74.5%

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   Температураcooling
2. 2
   workup.STIRRINGThe mixture is stirred at room temperature for 30 minutes
3. 3
   Фильтрацияthe precipitates are taken by filtration

Методика

A mixture of 5-fluoroisatin (9.9 g), triethylamine (1 ml) and dimethylformamide (30 ml) is stirred under ice-cooling, and thereto is added dropwise methyl isocyanate (3 g) at the same temperature. The mixture is stirred at room temperature for 30 minutes, and the precipitates are taken by filtration to give 5-fluoro-1-methylcarbamoylisatin (8.7 g). M.p. 230°-232° C.

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