Реакция #62816

Уравнение реакции

1-methylcyclohexyl 2-(p-nitrophenyl)-propionate

hydrogen

→

1-methylcyclohexyl 2-(p-aminophenyl)-propionate

Выход 67.1%

Растворители

—

petroleum ether

ethanol

Условия реакции

Обработка

1. 1
   Фильтрацияthe catalyst was filtered off through celite
2. 2
   Другоеthe filtrate was evaporated to dryness

Методика

A stirred solution of 34.9 g of 1-methylcyclohexyl 2-(p-nitrophenyl)-propionate in 250 ml of absolute ethanol was hydrogenated at atmospheric pressure in the presence of 10% palladium on carbon catalyst. After the uptake of hydrogen gas was complete, the catalyst was filtered off through celite and the filtrate was evaporated to dryness. Trituration of the residue with petroleum ether gave 21.02 g (67% yield) of 1-methylcyclohexyl 2-(p-aminophenyl)-propionate as creamy white crystals melting at 85°-87° C.

Источник