Реакция #62797

ord-89530f2a18254553b1cad6d2f1223cf2

Уравнение реакции

O=S(Cl)Cl
thionyl chloride
CC(=O)OCC(C)(COC(C)=O)C(=O)O
propionic acid
CC(=O)OCC(C)(COC(C)=O)C(=O)O
2,2-bis-acetoxymethyl propionic acid
→
CC(=O)OCC(C)(COC(C)=O)C(=O)Cl
2,2-bis-acetoxymethyl propionic acid chloride

Реактанты

—
2,2-bis-acetonxymethyl
O=S(Cl)Cl
thionyl chloride
CC(=O)OCC(C)(COC(C)=O)C(=O)O
propionic acid
CC(=O)OCC(C)(COC(C)=O)C(=O)O
2,2-bis-acetoxymethyl propionic acid

Реагенты

Нет

Условия реакции

Температура
100°CELSIUS
Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    workup.DISTILLATIONExcess thionyl chloride is distilled off in a water jet vacuum
  2. 2
    Другоеleaving a pale yellow, oily product

Методика

182 ml (2.5 moles) of thionyl chloride are poured over 218 g (1 mole) of 2,2-bis-acetonxymethyl propionic acid (step 1), followed by refluxing for 8 hours at a batch temperature of approximately 100° C. Excess thionyl chloride is distilled off in a water jet vacuum, leaving a pale yellow, oily product. Yield 236 g (100% of the theoretical).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US04762777uspto-grants-1988_08