Реакция #62785

Уравнение реакции

Trichloroacetyl chloride

N-(3-chloro)allyl-N-methoxyethylamine

triethylamine

→

above-named product

Выход 92.7%

N-(3-chloro)allyl-N-methoxyethyl trichloroacetamide

Выход 92.7%

Растворители

dichloromethane

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThe reaction was kept at approximately 5° C. with an ice-water bath
2. 2
   workup.ADDITIONUpon completion of the addition
3. 3
   ПромывкаThe reaction mixture was then washed twice with saturated brine
4. 4
   Сушкаdried with sodium sulfate
5. 5
   ДругоеRotary evaporation

Методика

N-(3-chloro)allyl-N-methoxyethylamine (2.25 g, 0.015 mol) and 1.52 g (0.015 mol) triethylamine were stirred in 70 ml dichloromethane. The reaction was kept at approximately 5° C. with an ice-water bath. Trichloroacetyl chloride (2.73 g, 0.015 mol) in 10 ml dichloromethane was added dropwise to the cooled solution. Upon completion of the addition, the mixture was stirred at room temperature for 6 hours. The reaction mixture was then washed twice with saturated brine and dried with sodium sulfate. Rotary evaporation yielded 4.1 g of the above-named product.

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