Реакция #62747

Уравнение реакции

water

ethylcyanoacetate

7,8-dimethoxy-5-formyl-2H-1-benzopyran

piperidine

→

orange solid

Выход 66.9%

Ethyl 2-cyano-3-(7,8-dimethoxy-2H-1-benzopyran-5-yl)propenoate

Выход 66.9%

Растворители

benzene

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураto cool
3. 3
   ЭкстракцияThe solution was extracted successively with water (200 mL), 0.5N hydrochloric acid (200 mL), saturated sodium bicarbonate solution (200 mL), H2O (200 mL)
4. 4
   Сушкаdried over magnesium sulfate
5. 5
   ДругоеThe volatiles were removed under reduced pressure

Методика

A mixture of ethylcyanoacetate (11.3 g, 0.1 mole), 7,8-dimethoxy-5-formyl-2H-1-benzopyran (22.0 g, 0.1 mole), piperidine (1.02 g, 0.01 mole) and acetic acid (0.36 g, 0.006 mole) in benzene (100 mL) was heated at reflux for 5 hr with azeotropic removal of water and allowed to cool. The solution was extracted successively with water (200 mL), 0.5N hydrochloric acid (200 mL), saturated sodium bicarbonate solution (200 mL), H2O (200 mL) and dried over magnesium sulfate. The volatiles were removed under reduced pressure to give 21.1 g (66.9%) of an orange solid, mp 104.5°-107.5° C.

Источник