Реакция #627351

ord-3de9ede325a542e29774f1bc142e33c1

Уравнение реакции

Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(N)c2c1
2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinolin-4-amine
CC(Br)C(=O)Cl
2-bromopropionyl chloride
[N-]=[N+]=[N-].[Na+]
sodium azide
Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(NC(=O)[C@H](C)N)c2c1
title compound
Cc1ccc2nc(N3CCS(=O)(=O)c4ccccc4C3)cc(NC(=O)[C@H](C)N)c2c1
N-[2-(1,1-Dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinolin-4-yl]alaninamide

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The title compound was prepared in analogy to Example 40-2 in Scheme 18 by using 2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinolin-4-amine, 2-bromopropionyl chloride and sodium azide. MS obsd. (ESI+) [(M+H)+] 425, 1H NMR (400 MHz, CD3OD) δ ppm 8.07-7.85 (m, 3 H), 7.64-7.51 (m, 2 H), 7.46-7.35 (m, 2 H), 5.22-5.08 (m, 2 H), 4.51-4.42 (m, 1 H), 3.65-3.53 (m, 2 H), 3.37 (s, 3 H), 2.51-2.40 (m, 3 H), 1.73 (d, J=7.07 Hz, 1 H), 1.30 (d, J=2.78 Hz, 2 H).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08871756B2uspto-grants-2014_10