Реакция #62614

Уравнение реакции

4-[(trimethylsilyl)oxy]-2H-1-benzopyran

ether

isopropyl ether

→

orange-red solid

Выход 86.0%

4H-Furo[3,2-c][1]benzopyran-2,3-dione

Выход 86.0%

Условия реакции

Обработка

1. 1
   ФильтрацияThe precipitate is collected by filtration
2. 2
   Промывкаwashed with isopropyl ether

Методика

To a stirred solution of 4-[(trimethylsilyl)oxy]-2H-1-benzopyran (L. H. Hellberg, and A. Zuarez, Tetrahedron Letters, 40, 3553 (1974)) (205.8 g, 0.917 mole) in anhydrous ether (600 ml) oxalyl chloride (58.2 g, 0.458 mole) is added dropwise over a period of 40 minutes at room temperature under nitrogen. The suspension is stirred at room temperature for 18 hours and then diluted with isopropyl ether (~300 ml). The precipitate is collected by filtration and washed with isopropyl ether to give 80.2 g (86%) of orange-red solid, mp 146°-8° C. Recrystallization from tetrahydrofuranisopropyl ether gives an analytical sample, mp 146°-148° C.

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