Реакция #624916

Уравнение реакции

Benzyl 2-cyclohexyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate

→

Benzyl 2-cyclohexyl-4-oxopiperidine-1-carboxylate

Растворители

AcOH

Условия реакции

Обработка

1. 1
   ФильтрацияThe solution was filtered through celite
2. 2
   Промывкаwashed with EtOAc
3. 3
   ДругоеThe solvent was evaporated under reduced pressure
4. 4
   Другоеthe product was purified by column chromatography on silica gel 30% EtOAc/Hexanes

Методика

Benzyl 2-cyclohexyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate (35.25 g, 112 mmol) was dissolved in AcOH (450 ml) and added zinc dust (22.07 g, 337 mmol). The solution stirred at room temperature for 12 hours. The solution was filtered through celite and washed with EtOAc. The solvent was evaporated under reduced pressure and the product was purified by column chromatography on silica gel 30% EtOAc/Hexanes.

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