Реакция #62300

Уравнение реакции

5-bromo-2,3-difluoro-4-trimethylsilanyl benzaldehyde

cesium fluoride

→

title compound

Выход 75.6%

5-Bromo-2,3-difluoro Benzaldehyde

Выход 75.6%

Растворители

N,N-dimethylformamide

water

ethyl acetate

Условия реакции

Обработка

1. 1
   Промывкаthe organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine
2. 2
   Сушкаdried over anhydrous magnesium sulfate
3. 3
   Другоеthe solvent was evaporated

Методика

To a solution of 18.0 g of 5-bromo-2,3-difluoro-4-trimethylsilanyl benzaldehyde in 20 mL of N,N-dimethylformamide and 2 mL of water was added 1.63 g of cesium fluoride at room temperature, and stirred at this temperature for 1 hour. After diluting with ethyl acetate, the organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 10.26 g of the title compound as a colorless oil.

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