Реакция #62281

Уравнение реакции

sodium hydrogen carbonate

3-naphthalen-2-yl-1-trityl-1H-pyrazolo[4,3-b]pyridine-5-carbonitrile

trifluoroacetic acid

→

title compound

Выход 94.8%

3-(Naphthalen-2-yl)-1H-pyrazolo[4,3-b]pyridine-5-carbonitrile

Выход 94.8%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Экстракцияextracted with ethyl acetate
2. 2
   Промывкаwashed with water
3. 3
   Сушкаdried over magnesium sulfate
4. 4
   ДругоеAfter evaporating
5. 5
   Другоеthe residue was purified
6. 6
   Другоеseparated by silica gel column chromatography (ethyl acetate:n-hexane=3:1)

Методика

To 10 mL of a solution containing 360 mg of 3-naphthalen-2-yl-1-trityl-1H-pyrazolo[4,3-b]pyridine-5-carbonitrile obtained by Production example 15 in dichloromethane, 3 mL of trifluoroacetic acid was added at room temperature and stirred for 2 hours. The reaction solution was added with aqueous sodium hydrogen carbonate, extracted with ethyl acetate, washed with water, and dried over magnesium sulfate. After evaporating, the residue was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=3:1), to afford 180 mg of the title compound as a colorless powder.

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