Реакция #62144

Уравнение реакции

4-(2-Quinolin-2-yl-ethyl)-benzoic acid

acetonitrile

O,N-Dimethyl-hydroxylamine hydrogen chloride

sodium hydroxide

→

title compound

Выход 88.0%

N-Methoxy-N-methyl-4-(2-quinolin-2-yl-ethyl)-benzamide

Выход 88.0%

Растворители

dioxane

triethylamine

Условия реакции

Обработка

1. 1
   Экстракцияextracted with chloroform, dried magnesium sulfate
2. 2
   Фильтрацияfiltered
3. 3
   Концентрированиеconcentrated
4. 4
   ПромывкаBiotage MPLC chromatography eluting with 20-50% ethyl acetate

Методика

To a solution of 4-(2-Quinolin-2-yl-ethyl)-benzoic acid (530 mg) in dioxane 5 ml/acetonitrile 5 ml was added triethylamine (0.60 ml) and O,N-Dimethyl-hydroxylamine hydrogen chloride (240 mg). After 72 h, the reaction mixture was poured into 1N sodium hydroxide solution and extracted with chloroform, dried magnesium sulfate, filtered and concentrated. Biotage MPLC chromatography eluting with 20-50% ethyl acetate provided the title compound (516 mg, 88%). MS: (M+H m/z=321.1).

Источник