Реакция #62019

Уравнение реакции

N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline

potassium phthalimide

Dimethyl formamide

→

N-[3-pthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholinyl)aniline

Растворители

water

Условия реакции

Обработка

1. 1
   Температураis heated for 5 hours
2. 2
   Температураat reflux temperature
3. 3
   Фильтрацияfiltered the solid
4. 4
   Другоеobtained
5. 5
   Другоеrecrystallized from isopropyl alcohol

Методика

The mixture of (N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline obtained in example 1, potassium phthalimide (40 gm) and Dimethyl formamide (400 ml) is heated for 5 hours at reflux temperature. The reaction mixture is cooled to ambient temperature, poured in to water (2 L) and filtered the solid obtained, and recrystallized from isopropyl alcohol to give 50 gm N-[3-pthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholinyl)aniline.

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