Реакция #619152

Уравнение реакции

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid benzyl ester

→

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid

Растворители

MeOH

Условия реакции

Обработка

1. 1
   Другоеto degas the mixture
2. 2
   Другое(24 h)
3. 3
   ФильтрацияAfter filtering
4. 4
   Концентрированиеconcentration
5. 5
   Другоеthe pure acid was obtained by trituration

Методика

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-3-carboxylic acid benzyl ester (30 mg, 0.057 mmol) was combined with palladium on carbon (20 mg) in MeOH. Vacuum was applied to degas the mixture. The reaction was subjected to hydrogen and vigorous stirring until no ester could be detected (24 h). After filtering and concentration, the pure acid was obtained by trituration.

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