Реакция #619150

Уравнение реакции

{[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-amino}-acetic acid tert-butyl ester

Hydrogen chloride

→

desired compound

Выход 76.0%

{[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-amino}-acetic acid

Выход 76.0%

Растворители

methylene chloride

diethyl ether

Условия реакции

Обработка

1. 1
   Концентрированиеconcentrated
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in a minimum amount of methylene chloride
3. 3
   Другоеprecipitated with diethyl ether
4. 4
   Другоеdecanted

Методика

{[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-amino}-acetic acid tert-butyl ester (14 mg, 0.03 mmol) was dissolved in methylene chloride. Hydrogen chloride (100 μL, 4N in dioxane) was added and the reaction was stirred at ambient temperature until no ester could be detected. The reaction was diluted with diethyl ether and concentrated. The resulting residue was dissolved in a minimum amount of methylene chloride, precipitated with diethyl ether and decanted. This was repeated to afford 9 mg (69%) of the desired compound. HPLC-MS: m/z 395 (M+1).

Источник