Реакция #619147

Уравнение реакции

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-2(R)-carboxylic acid benzyl ester

→

pure acid

Выход 84.8%

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-yl-methyl]-pyrrolidine-2(R)-carboxylic acid

Выход 84.8%

Растворители

MeOH

Условия реакции

Обработка

1. 1
   Другоеto degas the mixture
2. 2
   Другое(36 h)
3. 3
   ФильтрацияAfter filtering
4. 4
   Концентрированиеconcentration

Методика

1-[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-pyrrolidine-2(R)-carboxylic acid benzyl ester (50 mg, 0.095 mmol) was combined with palladium on carbon (25 mg) in MeOH. Vacuum was applied to degas the mixture. The reaction was subjected to hydrogen and vigorous stirring until no ester could be detected (36 h). After filtering and concentration, 35 mg (84%) pure acid was obtained by trituration.

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