Реакция #619133

ord-309363124f3d47cca025cb26264f3543

Уравнение реакции

NC(N)=O
urea
C[C@H]1CC[C@H](NC2CCCCC2)CC1
cyclohexyl-(trans-4-methyl-cyclohexyl)-amine
Nc1ncc(C=O)s1
2-amino-5-formylthiazole
→
C[C@H]1CC[C@H](N(C(=O)Nc2ncc(C=O)s2)C2CCCCC2)CC1
Trans-1-cyclohexyl-3-(5-formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-urea

Реактанты

NC(N)=O
urea
C[C@H]1CC[C@H](NC2CCCCC2)CC1
cyclohexyl-(trans-4-methyl-cyclohexyl)-amine
Nc1ncc(C=O)s1
2-amino-5-formylthiazole

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеPrepared in 40% (140 mg)
  2. 2
    Другоеyield

Методика

Prepared in 40% (140 mg) yield as described for 1,1-dicyclohexyl-3-5-formyl-thiazol-2-yl)-urea using cyclohexyl-(trans-4-methyl-cyclohexyl)-amine (195 mg, 1.0 mmol) and 2-amino-5-formylthiazole (128 mg, 1.0 mmol).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: USRE045183E1uspto-grants-2014_10