Реакция #619117

Уравнение реакции

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester

→

3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester

Выход 47.7%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеThe content was degassed
2. 2
   ФильтрацияThe mixture was filtered through celite
3. 3
   Концентрированиеthe filtrate was concentrated
4. 4
   ДругоеThe residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1

Методика

To a solution of 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-acrylic acid ethyl ester (Example 257) (75 mg, 0.18 mmol) in methanol was added Pd/C (150 mg). The content was degassed and was placed under hydrogen atmosphere for 12 h. The mixture was filtered through celite, and the filtrate was concentrated. The residue was further purified by flash chromatography (silica, CH2Cl2-EtOAc 4:1 to give 3-[2-(3,3-dicyclohexylureido)-thiazol-5-yl]-propionic acid ethyl ester (35 mg) in 47% yield.

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