Реакция #619112

ord-2d3837d2e1c64eefb75a25f62c4577ca

Уравнение реакции

CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCCC2)CC1
3-(5-bromothiazol-2-yl)-1-cyclohexyl-1-(4-methylcyclohexyl)-urea
CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCCC2)CC1
3-(5-Bromothiazol-2-yl)-1-cyclohexyl-1-(4-methyl-cyclohexyl)-urea
CCOC(=O)c1cnc(S)n1C
2-mercapto-3-methyl-3H-imidazole-4-carboxylic acid ethyl ester
→
CCOC(=O)c1cnc(Sc2cnc(NC(=O)N(C3CCCCC3)C3CCC(C)CC3)s2)n1C
2-{-2-[3-Cyclohexyl-3-(4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-3-methyl-3H-imidazole-4-carboxylic acid ethyl ester

Реактанты

CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCCC2)CC1
3-(5-bromothiazol-2-yl)-1-cyclohexyl-1-(4-methylcyclohexyl)-urea
CC1CCC(N(C(=O)Nc2ncc(Br)s2)C2CCCCC2)CC1
3-(5-Bromothiazol-2-yl)-1-cyclohexyl-1-(4-methyl-cyclohexyl)-urea
CCOC(=O)c1cnc(S)n1C
2-mercapto-3-methyl-3H-imidazole-4-carboxylic acid ethyl ester

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеPrepared

Методика

Prepared as described in general procedure (E) from 3-(5-bromothiazol-2-yl)-1-cyclohexyl-1-(4-methylcyclohexyl)-urea (Example 242) and 2-mercapto-3-methyl-3H-imidazole-4-carboxylic acid ethyl ester.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: USRE045183E1uspto-grants-2014_10