Реакция #619097

ord-54abd225bdcd4e8eaab6d1d8b8f78c7f

Уравнение реакции

O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCSCC1
3-(5-bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-thiopyran-4-yl)-urea
O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCSCC1
3-(5-Bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-thiopyran-4-yl)-urea
COC(=O)CS
methyl thioglycolate
→
COC(=O)CSc1cnc(NC(=O)N(C2CCCCC2)C2CCSCC2)s1
{2-[3-Cyclohexyl-3-(tetrahydro-thiopyran-4-yl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid methyl ester

Реактанты

O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCSCC1
3-(5-bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-thiopyran-4-yl)-urea
O=C(Nc1ncc(Br)s1)N(C1CCCCC1)C1CCSCC1
3-(5-Bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-thiopyran-4-yl)-urea
COC(=O)CS
methyl thioglycolate

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеPrepared

Методика

Prepared as described in general procedure (D) using 3-(5-bromo-thiazol-2-yl)-1-cyclohexyl-1-(tetrahydro-thiopyran-4-yl)-urea (Example 190) and methyl thioglycolate.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: USRE045183E1uspto-grants-2014_10