Реакция #619083

Уравнение реакции

Dicyclohexylamine

aminothiazole

carbonyldiimidazole

→

title product

1,1-Dicyclohexyl-3-thiazol 2 yl urea

Растворители

ethyl acetate

dichloromethane

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe reaction stirred overnight at room temperature
2. 2
   Промывкаwashed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL)
3. 3
   Сушкаdried over magnesium sulphate
4. 4
   Концентрированиеconcentrated in vacuo
5. 5
   Другоеthe residue purified by HPLC (Gilson 1, X-terra column; 0-100% CH3CN/H2O/0, 1% TFA; 15 min; flow 50 ml/min)

Методика

To a solution of aminothiazole (50 mg, 0.5 mmol) in dichloromethane was added carbonyldiimidazole (81 mg, 0.5 mmol) and the solution stirred 2 h at room temperature. Dicyclohexylamine (1 eq) was then added and the reaction stirred overnight at room temperature. The reaction mixture is then diluted with ethyl acetate (8 mL), washed successively with 10% sodiumhydrogensulphate (3 mL), water (3 mL), dried over magnesium sulphate, concentrated in vacuo, and the residue purified by HPLC (Gilson 1, X-terra column; 0-100% CH3CN/H2O/0, 1% TFA; 15 min; flow 50 ml/min) to give the title product (52 mg).

Источник