Реакция #618642

Уравнение реакции

1-(4-bromo-2-nitrophenyl)piperazine hydrochloride

2-chloroacetamide

sodium carbonate

→

titled compound

Выход 40.3%

2-(4-(4-bromo-2-nitrophenyl)piperazin-1-yl)acetamide

Выход 40.3%

Растворители

toluene ethanol

Условия реакции

Обработка

1. 1
   Другоеthe same reaction conditions

Методика

Using the same reaction conditions as described in step-i of example-82A, 1-(4-bromo-2-nitrophenyl)piperazine hydrochloride (1.2 g 3.69 mmol) was alkylated using 2-chloroacetamide (517 mg, 5.53 mmol) and sodium carbonate (930 mg, 11.07 mmol) in toluene/ethanol (15/15 mL) to get 510 mg (40.3% yield) of the titled compound. MS: m/z=343.0 (M+1).

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