Реакция #61817

Уравнение реакции

water

2-Chloromethyl-6-(3-chloro-phenyl)-pyridine

3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)phenol

sodium hydride

→

title compound

Выход 83.0%

2-(3-Chloro-phenyl)-6-[3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-pyridine

Выход 83.0%

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   workup.STIRRINGstirred
2. 2
   workup.WAITover night
3. 3
   Экстракцияthe mixture was extracted with ethyl acetate tree times
4. 4
   СушкаThe combined organic phases were dried (sodium sulphate)
5. 5
   Другоеevaporated

Методика

A solution of 97 mg (0.42 mmol) 3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)phenol in 4.0 ml N,N-dimethylformamide was treated at 0° C. with 17 mg (0.42 mmol) of 60% sodium hydride and stirred at 0° C. for 30 min. Then 100 mg (0.42 mmol) 2-Chloromethyl-6-(3-chloro-phenyl)-pyridine were added and stirred continued at r. t. over night. After addition of 8 ml water, the mixture was extracted with ethyl acetate tree times. The combined organic phases were dried (sodium sulphate) and evaporated. Chromatography on silica (eluent: ethyl acetate/n-heptane 2:1) gave 0.151 g (83%) the title compound as white powder.

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