Реакция #61816

Уравнение реакции

thionyl chloride

N,N-dimethylformamide

[6-(3-Chloro-phenyl)-pyridin-2-yl]-methanol

→

2-Chloromethyl-6-(3-chloro-phenyl)-pyridine

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   workup.ADDITIONThe mixture was poured on ice/sodium bicarbonate solution
2. 2
   Другоеthe organic phase separated
3. 3
   ЭкстракцияThe water phase is extracted with dichloromethane
4. 4
   ПромывкаThe combined organic phases were washed with water
5. 5
   Сушкаdried (sodium sulphate)
6. 6
   Другоеevaporated
7. 7
   Другоеthe obtained material (409 mg, 94%) used without further purification

Методика

433 mg (0.264 ml, 3.64 mmol) thionyl chloride were added drop by drop at 0° C. to a solution of 0.2 ml N,N-dimethylformamide (DMF) and 400 mg (1.82 mmol) [6-(3-Chloro-phenyl)-pyridin-2-yl]-methanol in 25 ml dichloromethane and stirred for 3 h at 0° C. The mixture was poured on ice/sodium bicarbonate solution and the organic phase separated. The water phase is extracted with dichloromethane. The combined organic phases were washed with water, dried (sodium sulphate), evaporated and the obtained material (409 mg, 94%) used without further purification.

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