Реакция #61804

Уравнение реакции

water

2-Chloromethyl-6-(4-chloro-phenyl)-pyridine

4-(4-[1,2,3]triazol-1-yl-butyl)phenol

sodium hydride

→

title compound

Выход 47.0%

2-(4-Chloro-phenyl)-6-[4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-pyridine

Выход 47.0%

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   workup.STIRRINGstirred
2. 2
   workup.WAITcontinued at r.t. over night
3. 3
   Другоеthe precipitate was isolated
4. 4
   Промывкаwashed thoroughly with water and n-heptane
5. 5
   ДругоеThe residue was dried at 40° C.
6. 6
   Другоеpurified by LC-MS

Методика

A solution of 89 mg (0.42 mmol) 4-(4-[1,2,3]triazol-1-yl-butyl)phenol in 4.0 ml N,N-dimethylformamide was treated at 0° C. with 17 mg (0.42 mmol) of 60% sodium hydride and stirred at 0° C. for 30 min. Then 100 mg (0.42 mmol) 2-Chloromethyl-6-(4-chloro-phenyl)-pyridine [ZA 6706809] were added and stirred continued at r.t. over night. After addition of 8 ml water, the precipitate was isolated, washed thoroughly with water and n-heptane. The residue was dried at 40° C. and purified by LC-MS to give 80.5 mg (47%) of the title compound as white powder.

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