Реакция #61797

Уравнение реакции

water

2-Chloromethyl-6-(4-trifluoromethoxy-phenyl)-pyridine

4-(4-[1,2,3]triazol-1-yl-butyl)phenol

sodium hydride

→

title compound

Выход 18.8%

2-[4-(4-[1,2,3]Triazol-1-yl-butyl)-phenoxymethyl]-6-(4-trifluoromethoxy-phenyl)-pyridine

Выход 18.8%

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   workup.STIRRINGstirred
2. 2
   workup.WAITcontinued at r.t. over night
3. 3
   Другоеthe precipitate was isolated
4. 4
   Промывкаwashed thoroughly with water, n-heptane and diethylether
5. 5
   ДругоеThe residue was dried at 40° C.

Методика

A solution of 37 mg (0.17 mmol) 4-(4-[1,2,3]triazol-1-yl-butyl)phenol in 2.0 ml N,N-dimethylformamide was treated at 0° C. with 7 mg (0.17 mmol) of 60% sodium hydride and stirred at 0° C. for 30 min. Then 50 mg (0.17 mmol) 2-Chloromethyl-6-(4-trifluoromethoxy-phenyl)-pyridine were added and stirred continued at r.t. over night. After addition of 4 ml water, the precipitate was isolated, washed thoroughly with water, n-heptane and diethylether. The residue was dried at 40° C. to give 15 mg (18%) of the title compound as white powder.

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