Реакция #61787

Уравнение реакции

water

sodium hydride

3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenol

3-chloromethyl-6-(4-chloro-phenyl)-2-methyl-pyridine

→

title compound

Выход 91.8%

6-(4-Chloro-phenyl)-2-methyl-3-[3-Methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-pyridine

Выход 91.8%

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   workup.STIRRINGstirring
2. 2
   Другоеcontinued at room temperature
3. 3
   Другое(r.t.) overnight
4. 4
   workup.STIRRINGwas stirred for 1 h
5. 5
   Другоеthe formed precipitate isolated by filtration
6. 6
   Промывкаwashed with water, water/methanol 1:1, ethyl acetate, and ether

Методика

33 mg (0.83 mmol) of 60% sodium hydride were added to at 0° C. to a solution of 172 mg (0.79 mmol) 3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenol in 8.0 ml N,N-dimethylformamide and stirred for 30 min. at 0° C. 200 mg (0.79 mmol) 3-chloromethyl-6-(4-chloro-phenyl)-2-methyl-pyridine were given to the reaction mixture and stirring continued at room temperature (r.t.) overnight. After addition of 16 ml water the mixture was stirred for 1 h, the formed precipitate isolated by filtration, washed with water, water/methanol 1:1, ethyl acetate, and ether. 324 mg (91%) of the title compound were obtained as slightly beige powder.

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