Реакция #61763

Уравнение реакции

water

sodium hydride

3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenol

3-chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine

→

title compound

Выход 63.0%

2-Methyl-3-[3-Methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenoxymethyl]-6-(4-trifluoromethyl-phenyl)-pyridine

Выход 63.0%

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   workup.STIRRINGstirring
2. 2
   Другоеcontinued at room temperature
3. 3
   Другое(r.t.) overnight
4. 4
   workup.STIRRINGwas stirred for 1 h
5. 5
   Другоеthe formed precipitate isolated by filtration
6. 6
   Промывкаwashed with water, water/methanol 1:1, and ether
7. 7
   ДругоеThe residue was purified by chromatography on silica (eluent: ethyl acetate)

Методика

36 mg (0.90 mmol) of 95% sodium hydride were added to at 0° C. to a solution of 173 mg (0.75 mmol) 3-methyl-4-(4-[1,2,3]triazol-1-yl-butyl)-phenol in 4.0 ml N,N-dimethylformamide and stirred for 30 min. at 0° C. 214 mg (0.75 mmol) 3-chloromethyl-2-methyl-6-(4-trifluoromethyl-phenyl)-pyridine (WO 2005/049573) were given to the reaction mixture and stirring continued at room temperature (r.t.) overnight. After addition of 8 ml water the mixture was stirred for 1 h, the formed precipitate isolated by filtration, washed with water, water/methanol 1:1, and ether. The residue was purified by chromatography on silica (eluent: ethyl acetate) to yield 227 mg (63%) of the title compound as white crystals.

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