Реакция #61660

Уравнение реакции

5-acetyl-7-benzyloxy-1H-quinolin-2-one

benzyltrimethylammonium dichloriodate

sodium carbonate

sodium sulphite

dichloroethane

→

7-benzyloxy-5-(2-chloro-acetyl)-1H-quinolin-2-one

Растворители

water

acetic acid

Условия реакции

Обработка

1. 1
   Другоеat 65° C
2. 2
   Промывкаwashed with water
3. 3
   Другоеdried

Методика

7.0 g (23.9 mmol) 5-acetyl-7-benzyloxy-1H-quinolin-2-one and 19.0 g (54.6 mmol) benzyltrimethylammonium dichloriodate are stirred in 43 mL acetic acid, 7 mL water and 147 mL dichloroethane at 65° C. After 4.5 hours the raction is stopped by the addition of 400 mL sodium carbonate solution and 50 mL 5% sodium sulphite solution. The insoluble constituents are suction filtered, washed with water and dried.

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