Реакция #61349

ord-4f5d889f41c34992aab0683fdd8afa16

Уравнение реакции

CC(=O)N1CC2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)O)C(C1)N2C(=O)OC(C)(C)C(Cl)(Cl)Cl

CC(=O)N1CC2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)O)C(C1)N2C(=O)OC(C)(C)C(Cl)(Cl)Cl

3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo-[3.3.1]non-6-ene-6,9-dicarboxylic acid 9-(2,2,2-trichloro-1,1-dimethylethyl) ester

Cc1cccc(CNC2CC2)c1C

cyclopropyl-(2,3dimethylbenzyl)amine

→

CC(=O)N1C[C@H]2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)N(Cc3cccc(C)c3C)C3CC3)[C@@H](C1)N2.O=CO

(rac.)-(1R*,5S*)-3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylic acid cyclopropyl-(2,3-dimethylbenzyl)amide formate salt

Реактанты

3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo-[3.3.1]non-6-ene-6,9-dicarboxylic acid 9-(2,2,2-trichloro-1,1-dimethylethyl) ester

cyclopropyl-(2,3dimethylbenzyl)amine

Реагенты

Нет

Условия реакции

Подробные условия

See reaction.notes.procedure_details.

Обработка

1
ДругоеSynthesized

Методика

Synthesized according to typical procedures H and E from bicyclononene BN10 and cyclopropyl-(2,3dimethylbenzyl)amine. LC-MS: Rt=0.91; ES+: 632.31.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07427613B2uspto-grants-2008_09