Реакция #61078

Уравнение реакции

6-bromo-2-pyridinamine

1-chloro-2-isocyanatoethane

→

title compound

Выход 66.0%

N-(6-Bromo-2-pyridinyl)-N′-(2-chloroethyl)urea

Выход 66.0%

Растворители

THF

Условия реакции

Обработка

1. 1
   ДругоеThe crude mixture was partitioned between CH2Cl2 and water
2. 2
   ДругоеThe phases were separated
3. 3
   Сушкаthe organic layer was dried over anh. Na2SO4
4. 4
   ФильтрацияThe solids were filtered
5. 5
   Другоеthe solvent evaporated

Методика

To a solution of 6-bromo-2-pyridinamine (1 g, 5.78 mmol) in anh. THF (25 mL), at r.t., under N2, was added 1-chloro-2-isocyanatoethane (1.2 mL, 2.5 eq) and the reaction mixture was stirred at r.t. for 18 hr. The crude mixture was partitioned between CH2Cl2 and water. The phases were separated and the organic layer was dried over anh. Na2SO4. The solids were filtered and the solvent evaporated to give the title compound (1.06 g, 66%) which was used in the next step without further purification.

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