Реакция #610711

Уравнение реакции

1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one

4-bromo-2-(trifluoromethyl)pyridine

trans-N,N′-dimethylcyclohexane-1,2-diamine

potassium phosphate

→

product

Выход 33.4%

1-(4-cyclopropylpyridin-3-yl)-3-(2-(trifluoromethyl)pyridin-4-yl)imidazolidin-2-one

Выход 33.4%

Условия реакции

Обработка

1. 1
   Другоеreagents and reaction conditions
2. 2
   Другоеto afford the crude product
3. 3
   ДругоеPurification by preparative HPLC

Методика

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 70 mg, 0.344 mmol) was reacted with 4-bromo-2-(trifluoromethyl)pyridine (93.5 mg, 0.413 mmol) 1,4-dioxane (5 mL), copper iodide (6.5 mg, 0.034 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (4.8 mg, 0.034 mmol) and potassium phosphate (219 mg, 1.034 mmol) to afford the crude product. Purification by preparative HPLC afforded 40 mg of the product (33% yield).

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