Реакция #60984

ord-46e076917c9e40fcb0f29e2c4b4576ef

Уравнение реакции

FC(F)(F)Oc1ccc(N2CCNCC2)cc1
1-(4-Trifluoromethoxy-phenyl)-piperazine
O=C(Cl)c1cc([N+](=O)[O-])ccc1N1CCOCC1
2-Morpholin-4-yl-5-nitro-benzoyl chloride
→
O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CCN(c2ccc(OC(F)(F)F)cc2)CC1
title compound
O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CCN(c2ccc(OC(F)(F)F)cc2)CC1
(2-Morpholin-4-yl-5-nitro-phenyl)-[4-(4-trifluoromethoxy-phenyl)-piperazin-1-yl]-methanone

Реактанты

FC(F)(F)Oc1ccc(N2CCNCC2)cc1
1-(4-Trifluoromethoxy-phenyl)-piperazine
O=C(Cl)c1cc([N+](=O)[O-])ccc1N1CCOCC1
2-Morpholin-4-yl-5-nitro-benzoyl chloride

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

The title compound was prepared according to the procedure described for example 46 from 1-(4-Trifluoromethoxy-phenyl)-piperazine and 2-Morpholin-4-yl-5-nitro-benzoyl chloride (74%%, yellow solid, MS (m/e): 481.2(M+H, 100%)

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07427612B2uspto-grants-2008_09